Computational Biology

I have been studying problems from computational biology for more than 14 years. My work to date primarily revolves around the use of pattern discovery as a tool for tackling very diverse problems from computational biology. Since 1996, I have been publishing on methods that showcase the use of data mining in these very diverse contexts: discovery of patterns in biological sequences (nucleic and amino acids), multiple sequence alignment, gene expression data, the functional and structural annotation of proteins directly from sequence, the characterization and prediction of local 3D structure directly from primary data, genes discovery in prokaryotic organisms, the annotation of complete genomes, RNA interference, etc.

Currently, a large part of my time is devoted to the development of computational methods for the study of the RNA interference phenomenon, the analysis of non-coding regions of eukaryotic genomes, the study of cancer from the standpoint of cell process regulation, and the study of the several viruses.

Our algorithms and techniques are being exploited in the context of research collaborations with colleagues around the world (see Collaborators for more details). The Publications links contains an up-to-date list of references to my published, computational biology work.



Over the years, there has also been extensive coverage of the work that has come out of my group. The following is a sample of links and references to some such articles.

  • Grammatical rules spell out new drugs

  • Grammar could help fight bacteria

  • Grammar may help fight bacteria

  • MIT's anti-microbial 'grammar' posits new language of healing

  • Tiny RNA, big possibilities

  • IBM and Genome Institute of Singapore collaboration may lead to better understanding of cell process regulation

  • IBM & Genome Institute of Singapore Research Enhances View of microRNAs’ Influence in Cells

  • New IBM Prediction Method Suggests Vastly More microRNAs and Targets Than Previously Thought

  • Picking pyknons out of the human genome

  • The genetic deadzone? IBM probes junk DNA

  • Salvage prospect for 'junk' DNA

  • 'DNA analysis' spots e-mail spam

  • DNA technique protects against 'evil' emails

  • IBM dissects the DNA of spam

  • IBM Research Joins Fight Against Spam

  • Big Blue Advancing In The Genomics Arena, ISB News Report, Spring 1998.

  • Linux Weekly News, November 05, 1998

  • Teiresias on the Hacker Trail, Wired News 11/98

  • Technology Alliance Focuses on Research, IBM Research Magazine, Issue 1, 1998.

  • Pattern Of Deception, IBM Research Magazine, Issue 1, 1999.

  • Daring To Think Deep: Decoding Proteins, IBM Research Magazine, Issue 2, 1999.

  • Into the Big Blue Yonder, MIT Technology Review 07/99.

  • Algorithms solve business problems, USA Today, January 26, 1999.

  • All seeing software keeps eye on hackers, The London Sunday Times, November 8, 1998.

  • Policing the computer underworld, Science 282, 1223b, November 13, 1998.